In art history, there are several depictions of women with blindfolds, each with different meanings. Often, these are representations of Justitia (Justice), who wears a blindfold to symbolize objectivity and impartiality. Other motifs include Salome, associated with the beheading of John the Baptist and frequently depicted blindfolded in Richard Strauss's opera, or femme fatale figures embodying a seductive and dangerous femininity.

In modern art, blindfolds can also symbolize political or social oppression.

In the case of Salome, the blindfold can symbolically represent the character's blindness, either literally or metaphorically, as a representation of ignorance, delusion, or moral blindness, particularly within the context of Salome's story, where her desire and resulting actions blind her to the consequences.